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Saracens face the daunting prospect of visiting Toulon without their England stars.
The north Londoners, who are sixth and two points off the Premiership play-offs, are forced to rest their England contingent after Mark McCall revealed he's prioritising the league over Europe.
Toulon, third in the Top 14, finished top of Pool 4, while Sarries could only muster fourth in Pool 3.
Give penalties away at your peril
The French side have the best goalkicking success rate in the tournament (93.8%) with Baptiste Serin slotting 12 of his 13 kicks at goal.
Toulon's defence is also impressive having made an average of 11.5 dominant tackles per game, which ranks second.
Sarries will likely rue the absence of Itoje and Willis
Maro Itoje and Tom Willis have made more involvements in carries, tackles and rucks than any other players in the Champions Cup: 236 and 228 respectively.
Saracens have the second-highest tackle success rate at 82.2%, while Willis has made 12 more tackles than any other player at a success rate of 90.9%.
But it's in attack where the three-time champions have struggled - averaging just two clean breaks per match in their first four fixtures, which is fewer than any other team.
Previous meetings
The two sides last faced off in the competition back in January 2017 when Sarries beat Toulon 10-3 at the Stone X. While, their last meeting at Stade Felix Mayol was in 2016 where Saracens ran out away winners 31-23.
In 2014, these teams contested the final where Toulon proved victorious with a 23-6 triumph.